Endocrine Abstracts

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Intrauterine infection, a common antecedent of premature birth, leads to increased levels of interleukin-1 (IL-1) in the amniotic fluid. IL-1 in amniotic fluid and cord blood is a risk factor for the postnatal development of chronic lung disease. On the other hand, intrauterine inflammation may protect the preterm newborn from respiratory distress syndrome. A single intra-amniotic injection of IL-1 given to fetal animals increases surfactant protein synthesis and surfactant po...

Introduction: Premature newborns are defined as babies born before 37 weeks of pregnancy and after 22 weeks of pregnancy as a viability limit. This study aimed to analyse growth characteristics at the age of second and third age and the prevention of metabolic diseases that may occur in adult age at an early phase.Methods: This study was conducted as a retrospective cohort study between May 2021 and October 2021 in 18 different Outpatient Clinics in Patn...

THE SENSITIVITY OF 123I-MIBG IN THE DETECTION OF HISTOLOGICALLY CONFIRMED CATECHOLAMINE-PRODUCING TUMOURS.M Ismail, R Foley, WM Drake, AB Grossman, PJ Jenkins, SL Chew, GMBesser, R Reznek, K Britton, JP MonsonDepartments of Endocrinology, Nuclear Medicine and Radiology, StBartholomew's Hospital (QMUL), London EC1A 7BERadionuclide imaging is widely used for the loc...

Case report: A 50-year-old man was referred by his family doctor to the emergency room in September 2020 for intermittent abdominal pain in the right upper quadrant for several months. He also mentioned weight loss and several episodes of fever with chills. The patient was an active smoker, consumed large amounts of alcohol, and had no known medical history, nor taking any medication. At physical examination, the patient appeared pale and cachectic, with tende...

Objectives: Radiation induces DNA double strand breaks (DSBs) that can be visualized and enumerated as microscopic γ-H2AX and 53BP1 foci. This study analysed the dose- and time-dependency of the DNA damage in blood lymphocytes in patients after a personalised high-activity 177Lu-DOTATATE treatment.Methods: We investigated multiple blood samples of three patients up to 96 h after personalised high-activity peptide receptor radionuclid...

Cardioprotective actions of urocortin (Ucn) I have been proposed by several studies and may play a critical role on stress adaptation. And one of the beneficial actions on cardiovascular cells may be anti-oxidative actions. In addition, Ucn I may be regulated by oxidative stress, therefore, the present study is designed to reveal anti-oxidative actions of Ucns on cardiomyocytes. Mouse atrial cell line, HL-1 cardiomyocytes, was cultured in standard Claycomb medium supplemented ...

The management of nonfunctioning adrenal masses is controversial. The size is usually the only criterion for surgical treatment. The objective was to study the progression of the tumor size and the follow-up of several cardiovascular risk parameters in patients with nonsurgical nonfunctioning adrenal masses.Retrospective longitudinal observational study of 24 patients (54.2% men) with nonfunctioning adenomas followed for five years without surgical treat...

Prostate cancer have been most cause of cancer death to men in recent, but there are not effective treatments for this cancer. In growth of prostate cancer, steroid hormones such as androgen play a role in their growth and survival. However, endocrine disrupting chemicals (EDCs) intend to bind the hormone receptor and induce the abnormal hormone response. EDCs have potency to activate estrogen receptor (ER) and androgen receptor (AR) mediated signaling pathways, and they cause...

Resveratrol (trans-3,4,5-trihydroxystilbene, RES), a phytoestrogen, exists in grape skin and red wine. Endocrine disrupting chemicals (EDCs) appear to promote the development and progression of the estrogen dependant cancers. In this study, we evaluated the inhibitory effect of RES on the cell growth and progression induced by various EDCs in BG-1 ovarian cancer cells expressing estrogen receptors (ERs). The various EDCs, i.e., bisphenol A (BPA), nonylphenol (NP), octylphenol ...